QC Associate III - Analytical Development for Immunotherapy

Join the forefront of groundbreaking research at theBeckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The Analytical Development / Quality Control (QC) team at the Center for Bioinnovation and Manufacturing seeks a Quality Control Associate III to support analytical development and cGMP testing (release and in-process) of Gene and Cellular Immunotherapy products.

Beyond routine QC activities, you will be developing and executing analytics that enable process development activities. This is a dynamic and fast-paced environment, and you must be capable of diving into and troubleshooting a variety of analytical situations, utilizing targeted literature searches and leveraging available resources to identify the best approaches. You will also be trained in assay qualification, project specific techniques and procedures to support various activities. Testing includes, but is not limited to, the following: cell culture, cell viability (automated and manual cell counts), Flow Cytometry, ELISA, qPCR, ddPCR, viral vector, PSC pluripotency testing, proliferation, potency and cytotoxicity assays.

As a successful candidate, you will:

• Apply aseptic techniques
• Perform the procedures/methods and testing for manufacturing products following established SOPs in cGMP facility and GMP laboratory under limited supervision.
• Support development and perform necessary in-house assays to release products, including viral vectors, cellular therapies, plasmid DNA and recombinant proteins.
• Maintain accurate inventory, support routine lab activities, and handle data entry and reporting.
• Develop and adapt analytical methodologies, process control plans, and new manufacturing procedures.
• Ensure equipment quality control, perform preventive maintenance, and troubleshoot lab instruments.
• Cooperate with QC and QA for cGMP compliance, complete required training, and support performance improvement.

Your qualifications should include:

• Bachelor's or Master's in biological sciences with 6-8 years (post-Bachelor's) or 5-8 years (post-Master's) lab experience. Biotechnology or pharmaceutical industry experience is preferred.
• Experience within molecular biology and cellular biology, protein chemistry, biostatistics, biosafety training, chemical safety training, and cGMP principles and practices.
• Experience working with release testing of cGMP products is desirable.
• Experience with cell viability (automated and manual cell counts), vector titer, multi-color flow cytometry, ELISA, RT-PCR, ddPCR, primary cell culture, iPSC culture, potency, and cytotoxicity assay experience.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

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